2018 was a year of exciting change at ISB.

Following our affiliation with Providence St. Joseph Health in 2017, Dr. Lee Hood stepped down as ISB president to focus on his role of chief science officer and senior vice president at PSJH. Dr. Jim Heath, a renowned scientist who has a long history with ISB, was named our new president, and immediately took on the role with an eye on the future.

Our 2018 Annual Report features a president’s letter from Dr. Heath that addresses some of the highlights of 2018 and offers a glimpse at what is coming in the very near future; an acknowledgement of the generous contributors who help fund the groundbreaking scientific research at ISB; a collection of our top news stories of the year; and a snapshot of ISB’s finances.

Dr. Jim Heath

From the desk of Dr. Jim Heath

Letter from the President

I proudly took over the role of ISB president on January 1, 2018. The mantle was passed to me by Dr. Lee Hood, a legend in the field of genomics and biology and ISB’s co-founder.

Since our inception in 2000 as the world’s first systems biology-focused institute, we have championed collaborative and cross-disciplinary science. These values are as important today as they were 19 years ago.

Furthermore, translational science -- quickly moving scientific breakthroughs from concept to clinic -- is a critical part of ISB’s mission, and one we are attaining thanks to our affiliation with Providence St. Joseph Health (PSJH), one of the largest not-for-profit health care providers in the U.S.

In 2018, we expanded our faculty with the addition of myself and Drs. Sean Gibbons, Jenn Hadlock, and Wei Wei. We have continued to play an important role with STEM education by working to ensure all students have access to quality education and by developing next-generation STEM curricula on behalf of teachers. We created the ISB Foundation Board to help support ISB’s research and education programs through philanthropy, and we wished a very happy 80th birthday to Lee Hood.

It was an exciting year to be sure, and 2019 continues that trend. We are fearlessly pursuing research areas where our scientists are uniquely positioned to make a difference, including cancer immunotherapy, scientific wellness, brain health, Lyme disease, and many more. We have also begun working with the PSJH system to incorporate some of the concepts of systems biomedicine to help evolve PSJH into a state-of-the-art learning health care system designed to improve health outcomes for all of its patients.

As we push forward in this new chapter in the life of ISB, we are excited to unveil a new brand and tagline. (You can see our new logo and branding elements on this Annual Report!) Ahead of our 20th anniversary in 2020, we felt it was time to re-introduce ISB to our community and the world. “Science Transforming Health:” These three words perfectly sum up our mission to change lives with our important work.

You will be seeing a lot more of ISB going forward. As part of our year-long anniversary celebration in 2020, we are partnering with Town Hall Seattle to put on a speaker series focusing on some of the most exciting topics in science. Additionally, we will have several ISB-hosted events where the public can come meet our scientists, learn about ISB, and help us change the world.

ISB has always been a problem-solving institute. We are proud of our storied past, and we look forward to a limitless future.



James R. Heath, PhD
President, ISB


For the Year Ending December 31, 2018


Statement of Activities
Dollars in Thousands

Grants & Contract Revenue
Investment & Other Income
Total Revenues
Research & Other Direct Costs
Management & General
Fundraising & Other
Total Expenditures
Decrease in Net Assets

Balance Sheet
Dollars in Thousands

Cash & Investments
Other Assets
Property & Equipment (Net)
Total Assets
Accounts Payable & Accrued Expenses
Deferred Revenues
Total Liabilities
Net Assets
Net Assets without Donor Restrictions
Net Assets with Donor Restrictions
Total Net Assets

Growth in Operations ($)


2018 Contributors

Thank you for your support

Steven & Alexandra Cohen Foundation
Carole Ellison
Lee Hood and Valerie Logan
Douglas Howe and Robin DuBrin
Craig and Marie Mundie
Mars, Inc.
Phelps Family Foundation
Roger M. Perlmutter
Washington Research Foundation
The Wilke Family Foundation
$25,000 - $99,999
The Boeing Company
Global Lyme Alliance
Franklin and Catherine Johnson
Merck and Co., Inc.
Dave and Sandra Sabey
$10,000 - $24,999
Amgen, Inc.
Discuren Charitable Foundation
Jim Heath
Indi Molecular
Dan Ling and Lee Obrzut
Chris and Barb Moe
Muckleshoot Charity Fund
Providence St. Joseph Health
Christine Schaeffer
Aron and Sara Thompson
Kevin Wold
$2,500 - $9,999
Terry Bergeson
Mark and Debby Blackman
Suzanne Burke
Clark Nuber P.S.
Dee Dickinson
Fenwick & West LLP
Gallagher Benefit Services, Inc.
The Greer/Solien Fund
Illumina, Inc.
Kilroy Realty Corporation
John Laughlin
Clayton Lewis and Tom Rasmussen
NanoString Technologies, Inc.
Gil Omenn and Martha Darling
Omeros Corporation
PACT Pharma
Bernhard Palsson
SomaLogic, Inc.
Brian Turner and Susan Hoffman
Mary Woolley
$1,000 - $2,499
Arne and Mary Anderson
Barbara Anderson
Marne Anderson
Nitin Baliga and Janet Ceballos
Laurie Black
Scott and Victoria Blair
Tom Brown
Bruker Daltonics, Inc.
Carolynne Bryant-Dowdy
JoAnn Chrisman
Myron and Sue Hood
Inyoul Lee and Myungkee Min
B Lippit and Liz Van Volkenburgh
Kerry and Cathy Loveland
Al and Peggy Luderer
Susan Marra
Marie Mentor
Nick Newcombe
Joe Notarangelo
Carl and Carole Scandella
Kathy Scanlan
Gretchen Sorensen
Erich Strauss
Thermo Fisher Scientific, Inc.
Jim and Paula Thomas
Tom Weingarten and Wendy Thon
Elaine and Larry Woo
$500 - $999
908 Devices Inc
Linda Byrnes
Hilde Cheroutre and Mitchell Kronenberg
Mark and Suellen Cholvin
Neal Cholvin
Eric Deutsch
Kimsey Fowler
Malcolm Harris
Bruce and Joanne Jones
Eric and Melissa Jones
Paul and Lucy Lange
Richard Leider
Cammi Libby
Tony and Pat Marshall
Cavan O'Keefe
Taunya Sell
University of Victoria
Waters Corporation
$250 - $499
John and Leslie Aitchison
Tony Byrd
Robert Dughi
Tim Eggers and Sally Shuler
Patrick Ehrman
Jason Hamlin
Stephanie Honan
Rebecca Johnson
Kyle and Susan Kinoshita
John Krull
Jon and Eva LaFollette
Sarah Li
Heather and Sid Logan
Mark and Stacie Ludden
Sean Mackay
Melinda Mann
Amoreena Miller
Steve and Beth Mullin
Hank Myers
Scott Parris
Nathan and Brenda Price
Jeff Ranish
Sally and Gil Reavis
Stephen Ross
Jennifer Seko
Sally Shuler
Barbara Smith
Bob Sotak
Bingyun Sun
Julie Thatcher
Wei Wei
Amy Woodruff
Up to $249
Anna Box
Mary Brunkow
Tom and Barbara Cable
Frank and Sherri Candelario
Becki Chandler
Jan Chalupny
Annie Delucchi
Bryan Dittmer
Jennifer and Matt Donelan
Rick Edmark
Jen Eklund
Stephen Eraker
Marne Evans
Simon Evans
Peggy Fine
Patricia Gaillard
Richard Gelinas
Therese Ghosn
Steve Handley
Eran Hood and Sonia Nagorski
Brian Horman
Audri Hubbard
Matt Idso
Barb Jagels
Brent Jones
Jeremy Johnson
Terri Johnston
Paul Kelley
Katie Kephart
Kathy Kimball
Up to $249
Katie Kinoshita
Kay Knight
Chris Lausted
Jessica Levine
Bill Longabaugh
Marybee and Bob Longabaugh
Charles Maki
Adina Mangubat
Linda Maxson
Bernard Miner
Monica Orellana
Don Padelford
Anne Proffitt
Shizhen Qin
Marian Royal
Brad Shigenaka
Jen Sorensen
Todd Smith and Sandra Porter
Barb Steffens
Bobbie Stern
Harmon H. Rulifson
Alexis Takasumi
Alisha Taylor
Joan Tolmie
Michael Tolley
Kalli Trachana
Victoria Uhl
Mary Margaret Welch
Kevin Wheeler
Alvin and Virginia Wickline
Yong Zhou

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2018 Highlights

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